Jason E Gestwicki Selected Research

Tauopathies

12/2023	Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy.
1/2021	Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.
1/2020	Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone.
1/2020	Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.
11/2018	SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.
5/2015	Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.
9/2014	Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.
9/2013	Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.
6/2013	Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.
4/2013	Imbalance of Hsp70 family variants fosters tau accumulation.

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Jason E Gestwicki Research Topics

Disease

22	Neoplasms (Cancer) 05/2024 - 01/2008
21	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2024 - 10/2004
18	Alzheimer Disease (Alzheimer's Disease) 08/2023 - 10/2004
15	Tauopathies 12/2023 - 09/2009
9	Breast Neoplasms (Breast Cancer) 05/2024 - 01/2010
7	Prostatic Neoplasms (Prostate Cancer) 04/2023 - 01/2018
4	Parkinson Disease (Parkinson's Disease) 01/2021 - 04/2012
4	X-Linked Bulbo-Spinal Atrophy 01/2015 - 05/2010
3	Infections 01/2022 - 11/2012
3	Frontotemporal Dementia (Semantic Dementia) 12/2019 - 04/2012
3	Huntington Disease (Huntington's Disease) 01/2015 - 04/2014
2	Neoplasm Metastasis (Metastasis) 05/2024 - 01/2019
2	COVID-19 10/2023 - 07/2022
2	Cataract (Cataracts) 01/2019 - 11/2015
2	Disease Progression 11/2018 - 01/2015
2	Proteostasis Deficiencies 11/2016 - 11/2014
2	Gaucher Disease (Gaucher's Disease) 08/2014 - 05/2006
2	Dementia (Dementias) 07/2012 - 11/2010
1	Malaria 03/2024
1	Neuroaxonal Dystrophies (Neuroaxonal Dystrophy, Late Infantile) 01/2024
1	Familial Hypertrophic Cardiomyopathy (Cardiomyopathy, Familial Hypertrophic) 09/2023
1	Medulloblastoma 01/2023
1	Carcinogenesis 01/2023
1	Thyroid Neoplasms (Thyroid Cancer) 01/2022
1	Multiple Myeloma 01/2022
1	Synucleinopathies 01/2021
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2020
1	Adenocarcinoma 01/2020
1	Colonic Neoplasms (Colon Cancer) 01/2020
1	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 01/2020
1	Legionnaires' Disease (Legionnaire's Disease) 01/2019
1	Muscular Diseases (Myopathy) 12/2018

Drug/Important Bio-Agent (IBA)

32	Proteins (Proteins, Gene)FDA Link 03/2024 - 10/2004
13	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 01/2023 - 11/2006
12	Molecular Chaperones (Chaperone, Molecular)IBA 01/2022 - 11/2006
8	polyglutamineIBA 11/2016 - 05/2010
7	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 08/2023 - 09/2011
7	Androgen Receptors (Androgen Receptor)IBA 04/2023 - 05/2010
6	Peptides (Polypeptides)IBA 10/2020 - 11/2006
4	EnzymesIBA 10/2023 - 05/2006
4	Carrier Proteins (Binding Protein)IBA 09/2023 - 04/2012
4	MKT 077IBA 01/2022 - 01/2012
4	Amyloid beta-PeptidesIBA 12/2010 - 11/2006
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 10/2020 - 11/2014
3	glucose-regulated proteinsIBA 10/2020 - 01/2020
3	Methylene Blue (Methylthioninium Chloride)FDA Link 04/2012 - 05/2010
2	CholesterolIBA 12/2023 - 01/2020
2	tau Proteins (tau Protein)IBA 12/2023 - 11/2010
2	Androgen Antagonists (Antiandrogens)IBA 01/2023 - 01/2018
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2023 - 10/2021
2	SynucleinsIBA 01/2021 - 01/2015
2	Phosphotransferases (Kinase)IBA 10/2020 - 01/2019
2	mortalinIBA 10/2020 - 01/2020
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 10/2020 - 01/2020
2	benzothiazoleIBA 01/2020 - 07/2018
2	Crystallins (Crystallin)IBA 01/2019 - 11/2015
2	Therapeutic UsesIBA 01/2019 - 11/2006
2	Protein Isoforms (Isoforms)IBA 01/2018 - 05/2015
2	N-(3-pyridylmethyl)adriamycin (YM 1)IBA 09/2014 - 01/2012
2	Glucosylceramidase (Glucocerebrosidase)IBA 08/2014 - 05/2006
2	rhodacyanineIBA 11/2013 - 01/2012
2	Adenosine Triphosphatases (ATPase)IBA 01/2010 - 09/2009
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2024
1	HSP72 Heat-Shock ProteinsIBA 05/2024
1	Messenger RNA (mRNA)IBA 05/2024
1	RNA (Ribonucleic Acid)IBA 05/2024
1	Antimalarials (Antimalarial Agents)IBA 03/2024
1	NAD (NADH)IBA 01/2024
1	Cholesterol Esters (Cholesteryl Esters)IBA 12/2023
1	Hydroxyl RadicalIBA 12/2023
1	Fatty Acids (Saturated Fatty Acids)IBA 12/2023
1	Myosins (Myosin)IBA 09/2023
1	AndrogensIBA 04/2023
1	UbiquitinIBA 01/2023
1	Eukaryotic Initiation Factor-4EIBA 01/2023
1	enzalutamideIBA 01/2023
1	Calcibiotic Root Canal SealerIBA 01/2023
1	Proteasome InhibitorsIBA 01/2022
1	MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA 10/2020
1	Glucose (Dextrose)FDA LinkGeneric 10/2020
1	pyridineIBA 01/2020
1	Lysine AcetyltransferasesIBA 01/2020
1	Firefly LuciferasesIBA 01/2020
1	BenzothiazolesIBA 01/2020
1	OxysterolsIBA 01/2019
1	VP1-001IBA 01/2019
1	Phenobarbital (Luminal)FDA Link 01/2019
1	CaspasesIBA 01/2019
1	Bacterial Proteins (Bacterial Protein)IBA 01/2019
1	CytokinesIBA 01/2019
1	Proline (L-Proline)FDA Link 12/2018
1	Small Heat-Shock ProteinsIBA 12/2018
1	Isoleucine (L-Isoleucine)FDA Link 12/2018
1	Valine (L-Valine)FDA Link 12/2018
1	Sirtuin 1IBA 11/2018

Therapy/Procedure

11	Therapeutics 04/2023 - 10/2004
3	Castration 04/2023 - 01/2018
1	Topical Administration 01/2019
1	Lenses 01/2019
1	Role Playing (Playing, Role) 01/2019